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MMP9 — SETD2
Text-mined interactions from Literome
Luo et al., Zhonghua Yi Xue Za Zhi 2006
(Neoplasm Invasiveness...) :
The expression of E-cadherin, vimentin,
MMP-2 , cathepsin D, and uPAR, all playing an established role in the invasion of tumor, can be
regulated by
HIF-1 in human prostate cancer cell
Higashida et al., J Neurosurg 2011
(Brain Edema...) :
Finally, while inhibition of
HIF-1a significantly ( p < 0.05 )
suppressed the expression of AQP-4 and
MMP-9 , such inhibition significantly ( p < 0.05 ) increased the expression of laminin and tight junction proteins
Lim et al., J Vasc Surg 2011
(Mechanotransduction, Cellular) :
Prolonged increases in vein wall tension are associated with overexpression of
HIF-1a and HIF-2a,
increased MMP-2 and
MMP-9 expression, and reduced venous contraction in rat IVC
Wan et al., Nanotoxicology 2011
:
Our results suggest that
HIF-1a accumulation may be
involved in the increased MMP-2 and
MMP-9 production in U937 cells exposed to Nano-Ni
Choi et al., Journal of breast cancer 2011
:
Luciferase and ChiP assays were performed to demonstrate that
MMP-9 promoter activity was
regulated by
HIF-1a ...
HIF-1a transactivated the
MMP-9 promoter by forming a transcriptional unit with p300, thus increasing expression of MMP-9 transcripts
Wang et al., J Mol Neurosci 2012
(Brain Edema...) :
Finally, inhibition of
HIF-1a significantly
suppressed the level of AQP-4 and
MMP-9 , which could induce the expression of laminin and tight junction proteins
Li et al., Mol Immunol 2013
(Arthritis, Rheumatoid) :
Knockdown or inhibition of
HIF-1a and NF-?B by small interfering RNA or specific small molecule inhibitors
blocked IL-17A mediated and hypoxia mediated MMP2 and
MMP9 expression, cell migration, and invasion
Fu et al., Ren Fail 2012
(Fibrosis) :
The expressions of
HIF-1a , TGF-ß1, MMP-9, and TIMP-1 were elevated and MMp-9/TIMP-1 ratio was lowered in the model group ( p < 0.05 ), but losartan
increased the expression of
MMP-9 and MMp-9/TIMP-1 ratio ( p < 0.05 ) and lessened the expressions of HIF-1a, TGF-ß1, and TIMP-1 ( p < 0.05 )