UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to PXN

CXCL12 — PXN

Pathways - manually collected, often from reviews:

NCI Pathway Database CXCR4-mediated signaling events: SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) → Paxillin (PXN) (modification, activates) Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
Evidence: mutant phenotype, assay, physical interaction

Text-mined interactions from Literome

Cohen-Hillel et al., Cell Mol Life Sci 2009 : In this study, we found that CXCL8 stimulation led to paxillin phosphorylation in normal neutrophils, and that both CXCL8 receptors ( CXCR1 and CXCR2 ) mediated CXCL8 induced paxillin phosphorylation
Gao et al., Stem Cells 2009 : Furthermore, stimulation of hMSCs with recombinant SDF-1 and tumor cell conditioned medium also significantly activated the focal adhesion kinases ( FAKs ) and paxillin , which correlated with reorganization of F-actin filaments in hMSCs
Ganju et al., J Biol Chem 1998 : Wortmannin, a selective inhibitor of phosphatidylinositol 3-kinase, partially inhibited the SDF-1alpha induced migration and tyrosine phosphorylation of paxillin