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CCND1 — CDC42
Text-mined interactions from Literome
Bauerfeld et al., Am J Physiol Lung Cell Mol Physiol 2001
:
Cdc42 , but not RhoA,
regulates cyclin D1 expression in bovine tracheal myocytes ... Here, we examined the
regulation of
cyclin D1 expression by
Cdc42 and RhoA ... Furthermore, dominant negative
Cdc42 , but not RhoA,
attenuated platelet derived growth factor mediated activation of the
cyclin D1 promoter ...
Cdc42 induced
cyclin D1 promoter activation was independent of ERK as evidenced by insensitivity to PD-98059, an inhibitor of mitogen activated protein kinase/ERK kinase ( MEK )
Roovers et al., Mol Cell Biol 2003
(MAP Kinase Signaling System) :
Inhibition of either MLCK or Rho kinase blocked sustained ERK signaling, but only Rho kinase inhibition allowed for the induction of
cyclin D1 and
activation of cdk4 via
Rac/Cdc42
Roovers et al., Dev Cell 2003
:
Instead, specific mutation of its nuclear localization and export sequences showed that LIM kinase acts in the nucleus to suppress
Rac/Cdc42 dependent
cyclin D1 expression