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CDC42 — RAD50

Text-mined interactions from Literome

Fukuyama et al., J Biol Chem 2005 : Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin induced activation of Cdc42 and formation of adherens junctions ... These results indicate that Rap1 is activated by nectins through the c-Src-Crk-C3G signaling and involved in the nectin induced, c-Src- and FRG mediated activation of Cdc42 and formation of AJs
Sato et al., Cancer Sci 2005 : The activation of Cdc42 and Rac by the trans-interaction of nectin and nectin is mediated by c-Src, another small G protein, Rap1 , a Cdc42-GEF, FRG, and a Rac-GEF, Vav2 ... The trans-interaction of Necl-5 and nectin-3 also activates Rap1 through C3G, a Rap-GEF, and this activation of Rap1 is required for the activation of Cdc42 and Rac
Gérard et al., J Cell Biol 2007 : Intracellular localization and activation of the Par complex are initiated by Rap1 and require Cdc42 activity
Hermand et al., Mol Cell 2007 : Rad26 directly binds Cdc18 and is required for Rad3 recruitment to chromatin ... Depletion of Cdc18 when DNA replication is stalled leads to release of Rad3 and Rad26 from chromatin and entry into an aberrant mitosis even though replication intermediates can still be detected
Kempf et al., Nat Med 2011 (Myocardial Infarction) : Mechanistically, GDF-15 counteracted chemokine triggered conformational activation and clustering of ß ( 2 ) integrins on PMNs by activating the small GTPase Cdc42 and inhibiting activation of the small GTPase Rap1