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CDH1 — TGFB3
Text-mined interactions from Literome
Chimal-Monroy et al., Int J Dev Biol 1999
:
Results showed that TGF-beta1, TGF-beta2,
TGF-beta3 , and TGF-beta5 differentially
enhanced the expression of
N-cadherin , N-CAM, fibronectin and tenascin in precartilage condensations, suggesting that TGF-beta isoforms play an important role in the establishment of cell-cell and cell-extracellular matrix interactions during precartilage condensations
Wang et al., J Cell Physiol 2001
(Colonic Neoplasms) :
Requirement of protein kinase Calpha, extracellular matrix remodeling, and cell-matrix interaction for
transforming growth factorbeta regulated expression of
E-cadherin and catenins
Nawshad et al., J Cell Sci 2007
:
TGFbeta3 inhibits
E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex
Buijs et al., Am J Pathol 2007
(Bone Neoplasms...) :
Exogenous addition of BMP7 to human prostate cancer cells dose-dependently inhibited
transforming growth factor beta induced activation of nuclear Smad3/4 complexes via ALK5 and
induced E-cadherin expression
Maretzky et al., J Invest Dermatol 2008
(Blister...) :
Proinflammatory cytokines,
transforming growth factor-beta , and lipopolysaccharide
led to increased release of soluble
E-cadherin by activating mitogen activated protein kinase signaling in cultured keratinocytes
Do et al., Mol Cancer Res 2008
(Neoplasm Metastasis...) :
When cancer cells were cultured on plastic, TGF-beta1, TGF-beta2, and
TGF-beta3 induced pro-matrix metalloproteinase ( MMP ) secretion, loss of cell-cell junctions, down-regulation of
E-cadherin , up-regulation of N-cadherin, and acquisition of a fibroblastoid phenotype, consistent with an epithelial-to-mesenchymal transition ... When cancer cells were cultured on plastic, TGF-beta1, TGF-beta2, and
TGF-beta3 induced pro-matrix metalloproteinase ( MMP ) secretion, loss of cell-cell junctions, down-regulation of
E-cadherin , up-regulation of N-cadherin, and acquisition of a fibroblastoid phenotype, consistent with an epithelial-to-mesenchymal transition