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CDK2 — ORC1

Pathways - manually collected, often from reviews:

• Reactome Reaction: CDK2 → ORC1 (reaction) Kumagai et al., Mol Cell Biol 1999, Jiang et al., EMBO J 1999, Méndez et al., Mol Cell 2002
• Reactome Reaction: CDK2 → ORC1 (indirect_complex) Kumagai et al., Mol Cell Biol 1999, Jiang et al., EMBO J 1999

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: ORC1 — CDK2 (physical association, affinity chromatography technology) Méndez et al., Mol Cell 2002
• IRef Biogrid Interaction: ORC1 — CDK2 (direct interaction, enzymatic study) Méndez et al., Mol Cell 2002
• IRef Hprd Interaction: ORC1 — CDK2 (in vitro) Méndez et al., Mol Cell 2002
• IRef Intact Interaction: Complex of CCNA2-CCNA1-ORC1-CDK2-ORC2 (association, coimmunoprecipitation) Méndez et al., Mol Cell 2002

Text-mined interactions from Literome

Findeisen et al., Eur J Biochem 1999 : We find that chromatin binding of ORC , Cdc6, and MCM proteins does not require cyclin dependent kinase activities
Hossain et al., Genes Dev 2012 (Growth Disorders...) : A cyclin binding motif (Cy motif) is required for Orc1 to bind Cyclin A and inhibit Cyclin A-CDK2 kinase activity but has no effect on Cyclin E-CDK2 kinase activity ... In contrast, Orc1 inhibition of Cyclin E-CDK2 kinase activity occurs by a different mechanism that is affected by Orc1 mutations identified in Meier-Gorlin syndrome patients
Fernández-Cid et al., Mol Cell 2013 : Importantly, CDK dependent phosphorylation of ORC inhibits OCM establishment to ensure once per cell cycle replication