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FRS2 — MAPK6
Text-mined interactions from Literome
Kornmann et al., Gastroenterology 2002
(Cell Transformation, Neoplastic...) :
In vitro, TAKA-1 cells stably transfected with FGFR-1 IIIc exhibited increased basal growth ; enhanced basal tyrosine phosphorylation of
FGFR substrate-2 (FRS2) , Shc, and phospholipase Cgamma ; and increased
activation of mitogen activated protein kinase (
MAPK )
Wu et al., Biol Chem 2003
:
Upon EGF stimulation,
FRS2 mediates enhanced
MAPK activity and undergoes phosphorylation on tyrosine as well as serine/threonine residues ... Upon EGF stimulation,
FRS2 mediates enhanced
MAPK activity and undergoes phosphorylation on tyrosine as well as serine/threonine residues
Yokote et al., Proc Natl Acad Sci U S A 2005
:
Moreover, both receptors stimulate tyrosine phosphorylation of the docking protein
FRS2alpha and
induce mitogen activated protein kinase stimulation with a time course and intensity that depends on the ligand that is applied
Easton et al., J Neurochem 2006
(Neuroblastoma) :
In addition to Shc, fibroblast growth
factor receptor substrate 2 (FRS2) is
required for the BDNF induced activation of
MAPK