Pozo et al., Cytokine 2002
:
In the present work, we studied the effect of VIP and PACAP on the CC chemokine macrophage inflammatory protein-1 alpha ( MIP-1alpha ) production in LPS stimulated RAW 264.7 macrophage cell line ... VIP and PACAP inhibited the production of MIP-1alpha in a dose dependent manner and over a broad spectrum of LPS concentrations ... By using selective PKA and PKC inhibitors and cAMP mimicked agents, we demonstrated a cAMP dependent signalling pathway for the inhibitory effect of VIP/PACAP on MIP-1alpha production, although a minor non mediated cAMP pathway was also involved
Sanchez et al., Neuropeptides 2009
:
PACAP38 dose-dependently increases immunodetectable levels of both RANTES and MIP-1alpha released in the media by cultured neurons