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ERBB2 — RAC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database a6b1 and a6b4 Integrin signaling: Rac1b/GTP complex (RAC1) → ErbB2 (ERBB2) (cell adhesion, collaborate) Hintermann et al., J Biol Chem 2005*, Chartier et al., J Cell Sci 2006
  Evidence: expresssion pattern, mutant phenotype, assay
• Reactome Reaction: ERBB2 → RAC1 (indirect_complex)

Text-mined interactions from Literome

Yang et al., Mol Cell Biol 2006 (Breast Neoplasms) : Using specific ErbB receptor inhibitors and depletion of receptors by RNA interference ( RNAi ), we established that, surprisingly, activation of Rac by HRG is mediated not only by ErbB3 and ErbB2 but also by transactivation of EGFR, and it is independent of ErbB4
Kawano et al., J Biol Chem 2009 : ErbB2 and ErbB3, members of the EGF receptor/ErbB family, form a heterodimer upon binding of a ligand, inducing the activation of Rac small G protein and Akt protein kinase for cell movement and survival, respectively
Johnson et al., J Biol Chem 2010 (Breast Neoplasms) : ErbB2 induction of migration requires activation of the small GTPases Rac1 and Cdc42