Counts et al., J Neurochem 2001
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The regulation of presenilin-1 by nerve growth factor ... NGF also induced PS1 fragment accumulation in cultured explants of rat dorsal root ganglia ... Quantitative northern blot analysis using PC12 cultures indicated that NGF did not increase steady-state PS1 mRNA levels
Powell et al., J Neurochem 2009
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In this study, we report the characterization of a highly conserved TRAF6 binding site ( PxExxAr/Ac ) in presenilin-1 (PS1) that mediates nerve growth factor (NGF) induced association between PS1 and TRAF6 ... In summary, our data suggest that an NGF induced association between PS1 and TRAF6 influences regulated intramembrane proteolysis of p75 ( NTR )