UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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ADAM17 — BDNF

Pathways - manually collected, often from reviews:

NCI Pathway Database p75(NTR)-mediated signaling: TACE (ADAM17) → proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGFR-BDNF-SORT1-TRAF6-ZNF274) (modification, activates)
Weskamp et al., J Biol Chem 2004
Evidence: mutant phenotype, other species