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FOS — SMAD3

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: AP1 complex (FOS-JUN) → SMAD2-3/SMAD4/SP1 complex (SMAD2_SMAD3-SMAD4-SP1) (transcription, activates)
  Brodin et al., J Biol Chem 2000
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SMAD3/SMAD4/JUN/FOS complex (SMAD3-SMAD4-FOS-JUN) → JUN (JUN) (transcription, activates) Wong et al., Mol Cell Biol 1999*, Inman et al., J Biol Chem 2002*
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: AP1 complex (FOS-JUN) → SMAD3/SMAD4 complex (SMAD3-SMAD4) (modification, collaborate)
  Zhang et al., Nature 1998*
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: AP1 complex (FOS-JUN) → SMAD3/SMAD4/JUN/FOS complex (SMAD3-SMAD4-FOS-JUN) (modification, collaborate)
  Zhang et al., Nature 1998*
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SMAD3/SMAD4 complex (SMAD3-SMAD4) → SMAD3/SMAD4/JUN/FOS complex (SMAD3-SMAD4-FOS-JUN) (modification, collaborate)
  Zhang et al., Nature 1998*
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: FOS — SMAD3 (physical association, affinity chromatography technology) Lee et al., PloS one 2011*
• IRef Biogrid Interaction: FOS — SMAD3 (direct interaction, two hybrid) Zhang et al., Nature 1998*
• IRef Biogrid Interaction: FOS — SMAD3 (direct interaction, pull down) Zhang et al., Nature 1998*
• MIPS CORUM SMAD3-SMAD4-cJun-cFos complex: SMAD3-SMAD4-cJun-cFos complex complex (FOS-JUN-SMAD3-SMAD4) Zhang et al., Nature 1998*
• IRef Corum Interaction: Complex of SMAD4-FOS-SMAD3-JUN (association, electrophoretic mobility supershift assay) Zhang et al., Nature 1998*
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Zhang et al., Nature 1998*
• IRef Hprd Interaction: FOS — SMAD3 (in vivo) Zhang et al., Nature 1998*
• IRef Hprd Interaction: FOS — SMAD3 (two hybrid) Zhang et al., Nature 1998*
• IRef Hprd Interaction: FOS — SMAD3 (in vitro) Zhang et al., Nature 1998*

Text-mined interactions from Literome

Feinberg et al., Circ Res 2004 (Hyperplasia...) : We demonstrate that the inhibitory effect of Smad3 occurs via a novel antagonistic effect of Smad3 on AP-1 DNA-protein binding and activity
Zhang et al., Am J Pathol 2006 : Furthermore, Smad3 blockade specifically inhibited activation of the transcription factor AP-1 by TGF-beta1, whereas PD98059 prevented TGF-beta1 dependent nuclear factor-kappaB activation
Sundqvist et al., Oncogene 2013 (Breast Neoplasms...) : Finally, chromatin immunoprecipitations showed that c-Jun, JunB and Fra1, but not c-Fos , are required for TGFß induced binding of Smad2/3 to the mmp-10 and pai-1 promoters