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CYP3A4 — IL6

Text-mined interactions from Literome

Jover et al., FASEB J 2002 (MAP Kinase Signaling System) : Our research has focused on the negative regulation of CYP3A4 ( the major drug metabolizing human CYP ) by interleukin 6 (IL-6) ( the principal regulator of the hepatic acute-phase response )
Yang et al., Toxicol Lett 2010 : Meanwhile, the repression of CYP3A4 by IL-6 occurred after the decrease of pregnane X receptor (PXR) in human hepatocytes ... The PXR overexpressed cells ( transfected with human PXR ) increased the CYP3A4 mRNA level, and the repression of CYP3A4 by IL-6 was greater in the PXR overexpressed cells than in the control cells ... Collectively, our study suggests that PXR is necessary for IL-6 mediated repression of the CYP3A4 expression in human hepatocytes
Dickmann et al., Drug Metab Dispos 2011 : A monoclonal antibody directed against IL-6 abolished or partially blocked IL-6 mediated suppression of CYP1A2 and CYP3A4 enzyme activity, respectively
Zhang et al., Expert Rev Clin Pharmacol 2011 (Arthritis, Rheumatoid) : Tocilizumab exposures are not affected by common concomitant medications in RA patients, but decreased IL-6 activity resulted in increased CYP3A4 activity and hence decreased exposures of CYP3A4 substrates
Kim et al., Rheumatol Int 2012 (Arthritis, Rheumatoid) : CYP3A4 mRNA expression was most reduced by IL-6 followed by CYP2C9 and CYP2C19