◀ Back to ABL1

ABL1 — CBL

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CBL → ABL1 (directlyIncreases, CBL Activity)
  Evidence: 9525940;9102067;12522270;11997497;10829062
• OpenBEL Selventa BEL large corpus: CBL → ABL1 (directlyIncreases, CBL Activity)
  Evidence: 12522270;12604776;10829062
• KEGG Pathways in cancer: ABL1/BCR → Complex of CBL-CBLB-CBLC-CRK-CRKL (protein-protein, activation)
  
• KEGG Chronic myeloid leukemia: ABL1/BCR → Complex of CBL-CBLB-CBLC-CRK-CRKL (protein-protein, activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CBL — ABL1 (direct interaction, enzymatic study) Grossmann et al., FEBS Lett 2004
• IRef Biogrid Interaction: CBL — ABL1 (physical association, affinity chromatography technology) Bhat et al., J Biol Chem 1997*
• IRef Biogrid Interaction: CBL — ABL1 (direct interaction, pull down) Reedquist et al., J Biol Chem 1996*
• IRef Biogrid Interaction: CBL — ABL1 (physical association, affinity chromatography technology) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Biogrid Interaction: CBL — ABL1 (physical association, affinity chromatography technology) Nishihara et al., Int J Hematol 2003*
• IRef Biogrid Interaction: CBL — ABL1 (physical association, affinity chromatography technology) Soubeyran et al., Biochem J 2003*
• IRef Biogrid Interaction: CBL — ABL1 (physical association, affinity chromatography technology) Miyoshi-Akiyama et al., Oncogene 2001*
• IRef Biogrid Interaction: CBL — ABL1 (direct interaction, enzymatic study) Miyoshi-Akiyama et al., Oncogene 2001*
• IRef Biogrid Interaction: CBL — ABL1 (direct interaction, far western blotting) Miyoshi-Akiyama et al., Oncogene 2001*
• IRef Biogrid Interaction: CBL — ABL1 (direct interaction, enzymatic study) Tsukahara et al., Blood 2010
• IRef Biogrid Interaction: CBL — ABL1 (direct interaction, pull down) Shishido et al., Proc Natl Acad Sci U S A 2000*
• IRef Biogrid Interaction: CBL — ABL1 (physical association, affinity chromatography technology) Patel et al., Genes Chromosomes Cancer 2006*
• IRef Biogrid Interaction: CBL — ABL1 (physical association, affinity chromatography technology) Johnson et al., PloS one 2009*
• IRef Biogrid Interaction: CBL — ABL1 (physical association, affinity chromatography technology) Shishido et al., Proc Natl Acad Sci U S A 2000*
• IRef Biogrid Interaction: CBL — ABL1 (direct interaction, pull down) Bhat et al., J Biol Chem 1997*
• IRef Biogrid Interaction: CBL — ABL1 (direct interaction, far western blotting) Bhat et al., J Biol Chem 1997*
• IRef Biogrid Interaction: CBL — ABL1 (direct interaction, pull down) Gaston et al., Exp Hematol 2004*
• IRef Biogrid Interaction: CBL — ABL1 (direct interaction, pull down) Jain et al., Oncogene 1997*
• IRef Hprd Interaction: Complex of CBL-ABL1-CRKL-ABL1-CBL-CRKL-CRKL-ABL1-CBL (in vivo) Grossmann et al., FEBS Lett 2004
• IRef Hprd Interaction: Complex of NCK1-CBL-ABL1-NCK1-NCK1-CBL-ABL1-ABL1-CBL (in vivo) Miyoshi-Akiyama et al., Oncogene 2001*
• IRef Hprd Interaction: Complex of ABL1-GRB2-CBL-GRB2-CBL-CBL-ABL1-GRB2-ABL1 (in vivo) Gaston et al., Exp Hematol 2004*
• IRef Hprd Interaction: Complex of CBL-ABL1-PIK3R2-CBL-ABL1-PIK3R2-CBL-ABL1-PIK3R2 (in vivo) Grossmann et al., FEBS Lett 2004
• IRef Hprd Interaction: CBL — ABL1 (in vivo) Soubeyran et al., Biochem J 2003*
• IRef Hprd Interaction: CBL — ABL1 (in vitro) Soubeyran et al., Biochem J 2003*
• IRef Intact Interaction: CBL — ABL1 (phosphorylation reaction, experimental interaction detection) Grossmann et al., FEBS Lett 2004
• IRef Ophid Interaction: CBL — ABL1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Miyoshi-Akiyama et al., Oncogene 2001 : Co-expression of wt Cbl together with c-Abl, the activity of which is normally repressed in vivo, led to extensive Abl dependent phosphorylation of Cbl
Mao et al., Proc Natl Acad Sci U S A 2010 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia
Salgia et al., Exp Hematol 1996 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl