Gene interactions and pathways from curated databases and text-mining

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CRP — ICAM1

Text-mined interactions from Literome

Blann et al., Blood Coagul Fibrinolysis 2003 : Effects of C-reactive protein on the release of von Willebrand factor, E-selectin, thrombomodulin and intercellular adhesion molecule-1 from human umbilical vein endothelial cells ... We found that increased release of thrombomodulin was induced by 20 and 50 microg/ml CRP after 48 h. Increased ICAM-1 was induced by 50 microg/ml CRP after 24 and 48 h
Montecucco et al., Rheumatology (Oxford) 2009 : Statins inhibit C-reactive protein induced chemokine secretion, ICAM-1 upregulation and chemotaxis in adherent human monocytes ... Statins inhibited CRP induced chemokine secretion, ICAM-1 up-regulation and migration in human adherent monocytes, through the inhibition of HMG-CoA reductase-ERK 1/2 pathway
Wynants et al., Eur Respir J 2012 (Hypertension, Pulmonary...) : Recombinant CRP effects on mitogenic activity, adhesion capacity, endothelin-1 and von Willebrand factor (vWF) secretion and intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule-1 expression were investigated in ECs and/or SMCs. Expression of the CRP receptor, lectin-like oxidised low-density lipoprotein receptor ( LOX ) -1, was evaluated in proximal pulmonary arterial tissue and cells by Western blotting and immunofluorescence
Edgar et al., Clin Sci (Lond) 1994 (Bacterial Infections...) : 4. Increased plasma intercellular adhesion molecule-1 levels were a highly sensitive ( 88 % ) indicator of clinical infection and were independent of C-reactive protein