Crean et al., FASEB J 2004
:
Furthermore, CTGF stimulated phosphorylation and activation of GSK-3beta Furlong et al., American journal of physiology. Renal physiology 2007
(Diabetic Nephropathies...) :
In high ambient glucose basal PKC-zeta and GSK3beta phosphorylation levels are selectively increased and CTGF stimulated PKC-zeta and GSK3beta phosphorylation was impaired
Smerdel-Ramoya et al., J Cell Biochem 2010
:
CTGF increased the mRNA levels of Protein kinase cyclic guanosine monophosphate ( cGMP ) dependent type II ( Prkg2 ), the gene encoding for cGMP dependent protein kinase II (cGKII) which phosphorylates GSK3beta ... Accordingly, CTGF induced GSK3beta phosphorylation and decreased the active pool of GSK3beta, a kinase that phosphorylates NFAT and leads to its nuclear export