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ATF2 — GRAP2
Text-mined interactions from Literome
Fuchs et al., J Biol Chem 2000
(MAP Kinase Signaling System) :
This effect is mediated by
JNK/p38 dependent phosphorylation of
ATF2 at Thr-69 and Thr-71, because the phosphorylation-deficient mutant ( ATF2 ( Delta150-248-T69A, T71A ) ) was not protected from ubiquitination and degradation by the activation of SAPK
Adachi et al., J Immunol 2000
:
SB202190, a p38 inhibitor, blocked
p38 dependent phosphorylation of
activating transcription factor-2
Yang et al., Nan Fang Yi Ke Da Xue Xue Bao 2006
:
His-TAT-p38 was found capable of increasing the activity of endogenous p38 in ECV304 cells, but
His-TAT-p38 ( AF )
inhibited the phosphorylation of
ATF2 so as to block the transduction of p38 signal pathway when the cells were stimulated with sorbitol
Wright et al., J Biol Chem 2007
:
In the present study raising cytosolic calcium resulted in increases in phosphorylation of p38 mitogen activated protein kinase and
activating transcription factor-2 , which were
blocked by the calcium/calmodulin dependent protein kinase inhibitor KN93 and by the
p38 mitogen activated protein kinase inhibitor SB202190
Zdanov et al., Biogerontology 2009
:
In this work,
p38 ( MAPK )
activation and increased DNA binding activities of
ATF-2 and p53 are shown to mediate cyclooxygenase-2 overexpression in premature senescence
Hosseini et al., Neurol Res 2010
(Neurodegenerative Diseases) :
This study revealed that camptothecin induces P38 expression and P38 in embryonic cortical neurons to determine the importance of the P38 pathway in neuronal death following DNA damage, and
P38 is
induce phosphorylation of
ATF-2 in embryonic cortical neurons following DNA damage
Chen et al., J Biol Chem 1998
(Brain Neoplasms) :
The
involvement of
p38 ( MAPK ) in the activation of
ATF-2 , which leads to the transactivation of rat grp78, is confirmed by electrophoretic mobility shift assay using a probe containing the CRE-like sequence as well as by transient transfection assays with a plasmid containing a 710-base pair stretch of the grp78 promoter