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HIF1A — MMP2
Text-mined interactions from Literome
Luo et al., BJU Int 2006
(Neoplasm Invasiveness...) :
The expression of E-cadherin, vimentin, cathepsin D,
MMP-2 and uPAR, which are proteins with established roles in the pathophysiology of invasion, could be
regulated by
HIF-1alpha in human prostate cancer cells
Shyu et al., Exp Cell Res 2007
(Adenocarcinoma...) :
Mechanistic studies revealed that
HIF-1alpha overexpression could
increase the expression of uPAR and MMP1, but not
MMP2 ... However, ELISA assays on the conditioned media generated from control CL1 and CL1 cells overexpressing HIF-1alpha showed that overexpression of
HIF-1alpha increased the levels of endogenous free active
MMP2 and total free MMP2, and the former was blocked by inhibition of MMP1 expression ... We conclude that ( i ) HIF-1alpha overexpression enhances lung cancer cell invasion at least through up-regulating the expression and activities of uPAR, MMP1, and MMP2 ; and ( ii ) induction of MMP1 participates in cell invasion and also plays an important role in
HIF-1alpha induced activation of
MMP2
Fan et al., Zhonghua Gan Zang Bing Za Zhi 2007
(Anoxia) :
HIF-1alpha may
play a part in the regulation of
MMP-2 transcription under hypoxic conditions
Xie et al., Chin J Cancer 2008
:
This study was to investigate the
effect of silencing
HIF-1alpha by RNA interference on the expression of
matrix metalloproteinase-2 (MMP-2) in human cervical carcinoma HeLa cells, and to further explore the mechanism
Ding et al., Brain Res 2009
(Brain Injuries) :
Inhibition of
HIF-1alpha reduced expression of
MMP-2 and -9
Kang et al., Clin Exp Pharmacol Physiol 2009
(Diabetes Mellitus, Experimental...) :
Impairment of ischaemia induced EPC mobilization in the diabetic mouse model is associated with altered
HIF-1 alpha/VEGF and
MMP/TIMP regulation and represents a novel mechanism underlying defective postischaemic neovascularization in diabetes
Lee et al., J Cell Physiol 2010
:
Consequently, the increased
HIF-1alpha expression
induced activation of
matrix metalloproteinase (MMP)-2 and MMP-9
Jing et al., Dis Esophagus 2013
(Esophageal Neoplasms...) :
Small interfering RNA could block
HIF-1 alpha effectively under hypoxia, then enhanced E-cadherin expression and
inhibited MMP-2 expression, respectively