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CSF3 — TLR5

Text-mined interactions from Literome

Fukuzono et al., Arch Biochem Biophys 2010 : We studied the effect of G-CSF on TLR agonist induced cytokine production in human neutrophils ... G-CSF and GM-CSF did not affect TLR agonist induced phosphorylation of ERK, p38, JNK, Akt, and IkappaBalpha ... G-CSF mediated STAT3 phosphorylation and inhibition of TLR agonist induced cytokine production were prevented by pretreatment of cells with AG-490 ( JAK2 inhibitor ) ... These findings suggest that G-CSF and GM-CSF exert the opposite effects on TLR agonist induced cytokine production, and G-CSF negatively regulates TLR agonist induced cytokine production in neutrophils via activation of STAT3
Krivokrysenko et al., J Pharmacol Exp Ther 2012 : Induction of both G-CSF and IL-6 by CBLB502 1 ) is strictly TLR5 dependent , 2 ) occurs in a CBLB502 dose dependent manner within its efficacious dose range in both nonirradiated and irradiated mammals, including nonhuman primates, and 3 ) is critically important for the ability of CBLB502 to rescue irradiated animals from death