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ADCY2 — IL1A
Text-mined interactions from Literome
Rodan et al., J Immunol 1990
(Bone Resorption...) :
Although
IL-1 had no effect on PGE2 synthesis, both IL-1 alpha and IL-1 beta
enhanced PGE2 stimulation of
adenylate cyclase two- to four-fold in a dose dependent manner ...
IL-1 did not
enhance basal
adenylate cyclase or stimulation by parathyroid hormone, isoproterenol, or forskolin
Schettini et al., Endocrinology 1990
:
The
effects of
IL1 on
adenylate cyclase activity and calcium fluxes were reversed by preincubation of the monokine with its polyclonal antibody, thus confirming the specificity of the effects
Făgăraşan et al., Proc Natl Acad Sci U S A 1989
(Pituitary Neoplasms) :
This suggests that
IL-1 does not
induce adenylate cyclase and that forskolin causes the secretion of beta-endorphin by a mechanism independent of cAMP
Fukuoka et al., Endocrinology 1989
:
IL-1 also significantly reduced intra- and extracellular cAMP accumulation by the cells in response to forskolin ( 50, 150 microM ) by 28-46 %, indicating that
IL-1 can directly
inhibit adenylate cyclase activity