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IL1A — NFKBIA

Text-mined interactions from Literome

Madge et al., J Biol Chem 1999 : IL-1 induced IkappaBalpha degradation was unaffected by these treatments
Sizemore et al., Mol Cell Biol 1999 : Specific PI3K inhibitors strongly inhibit both PI3K activation and NF-kappaB dependent gene expression but have no effect on the IL-1 stimulated degradation of IkappaBalpha , the nuclear translocation of NF-kappaB, or the ability of NF-kappaB to bind to DNA
Bourke et al., J Biol Chem 2000 : Stimulation with IL-1 also causes rapid but transient degradation of IkappaB-alpha and IkappaB-epsilon
Kamthong et al., Biochem J 2001 : In addition, we observed that forskolin potentiated and prolonged the IL-1 induced IkappaBalpha mRNA levels, whereas it did not stabilize the IkappaBalpha mRNA message
Stramer et al., Invest Ophthalmol Vis Sci 2001 : Both freshly isolated and activated stromal cells degraded IkappaBalpha in response to IL-1alpha ; yet, only activated stromal cells maintained autocrine IL-1alpha expression after 24 hours
Tago et al., Eur J Biochem 2001 : Moreover, genistein enhanced the IL-1alpha dependent degradation of IkappaBalpha
Chen et al., J Biol Chem 2002 : In human embryonic kidney 293 cells, IL-1beta induces IkappaB kinase beta (IKKbeta) activation, IkappaBalpha degradation, NF-kappaB transactivation, and weak Akt activation
Takehana et al., Biochem Biophys Res Commun 2002 : Despite having a strong inhibitory effect on the NF-kappaB dependent transcriptional activation, APC0576 does not inhibit the IL-1 induced DNA binding of NF-kappaB, degradation of I-kappaB-alpha , or phosphorylation of RelA ( p65 )
Mendes et al., J Cell Biochem 2003 : Treatment with superoxide dismutase, however, effectively prevented IL-1 induced I kappa B-alpha degradation and iNOS expression ... Taken together, the results obtained indicate that superoxide mediates IL-1 induced I kappa B-alpha degradation and the consequent NF-kappa B activation and iNOS expression in chondrocytes, whereas H ( 2 ) O ( 2 ) does not seem to participate in those IL-1 induced responses
Lee et al., J Immunol 2003 : In contrast, IL-1 beta induced NF-kappa B activity and I kappa B alpha degradation were not affected by BMP-7
Kim et al., J Neurochem 2004 : IL-1 or IL-1/IFNbeta induced RANTES/CCL5 expression was inhibited by the super-repressor IkappaBalpha or inhibitors of p38 or c-Jun N-terminal kinase (JNK) MAPKs ( mitogen activated protein kinases ), but not by extracellular signal regulated kinases ( ERK ) inhibitors
Wang et al., Am J Physiol Lung Cell Mol Physiol 2005 : As expected, IL-1beta stimulated translocation of NF-kappaB into the nucleus and degradation of IkappaB-alpha were blocked by helenalin but not by U0126, SB-202190, or SP-600125
Kiss et al., J Neurochem 2005 : IL-1 effectively induced the degradation of inhibitor of NF-kappaBalpha (IkBalpha) and IkBepsilon in both cell types but IkBbeta was not affected
Curran et al., J Biol Chem 2005 (Astrocytoma...) : However R ( + ) WIN 55,212-2 failed to inhibit IL-1 induced degradation of IkappaBalpha , excluding IKK-2 as a direct target
Li et al., Acta Pharmacol Sin 2006 (Pulmonary Disease, Chronic Obstructive) : NAC inhibited the phosphorylation of IKKbeta, IKK alpha, and IkappaB alpha induced by TNF-a, but had no effect on the phosphorylation of IKKbeta, IKK alpha and IkappaB alpha induced by IL-1 ... PDTC did not inhibit the phosphorylation of IkappaB alpha induced by TNF- alpha or IL-1
Lu et al., Exp Eye Res 2006 (Corneal Ulcer) : IL-1 induced the phosphorylation and degradation of IkappaB-alpha , the nuclear translocation and up-regulation of the DNA binding activity of the p65 subunit of NF-kappaB, and the activation of NF-kappaB in a manner sensitive to sulfasalazine
Jarvis et al., J Virol 2006 : IL-1 and TNF-alpha signaling pathways converge at a point upstream of NF-kappaB activation and involve phosphorylation and degradation of the NF-kappaB inhibitory molecule IkappaBalpha
Qin et al., J Biol Chem 2006 : We recently found that TLR8 mediates a unique NF-kappaB activation pathway in human 293 cells and mouse embryonic fibroblasts, accompanied only by IkappaBalpha phosphorylation and not IkappaBalpha degradation, whereas interleukin (IL)-1 stimulation causes both IkappaBalpha phosphorylation and degradation
Xu et al., Am J Physiol Cell Physiol 2006 (MAP Kinase Signaling System) : In cultured rat VSMCs, IL-1beta activated ERK and induced degradation of both IkappaBalpha and IkappaBbeta, which was associated with nuclear translocation of both ribosomal S6 kinase (RSK)1 and NF-kappaB p65
Liang et al., J Cell Physiol 2007 (MAP Kinase Signaling System) : Furthermore, IL-1beta stimulated translocation of NF-kappaB into the nucleus and degradation of IkappaB-alpha was blocked by helenalin
Newton et al., J Pharmacol Exp Ther 2007 (Pulmonary Disease, Chronic Obstructive) : In A549 cells, interleukin (IL)-1beta and tumor necrosis factor (TNF) alpha increased phosphorylation of IkappaBalpha , and this was followed by loss of IkappaBalpha, induction of NF-kappaB DNA binding, and the induction of NF-kappaB dependent transcription
Cahill et al., J Biol Chem 2008 : Neither inhibition of PI 3-kinase/AKT nor IKKalphaT23A overexpression affected IkappaBalpha degradation in response to IL-1
Luo et al., Toxicol Appl Pharmacol 2008 : Consistently, IL-1beta stimulated both IkappaB-alpha degradation and NF-kappaB translocation into nucleus in these cells
Ahmad et al., J Immunol 2009 : In addition, IL-1beta induced phosphorylation of downstream effectors, IkappaB kinase alphabeta, IkappaBalpha , and activation of transcription factor NF-kappaB was significantly reduced in the MyD88-, IRAK1-, TRAF6-, or Ras-deficient cells
Neves et al., Planta Med 2010 : Similarly to the effect of the whole oil, a fraction containing 93 % alpha-pinene reduced significantly IL-1 induced I kappaB-alpha degradation
Zhang et al., Molecular vision 2009 : Furthermore, BOL-303242-X inhibited IL-1ss induced decreases in IkappaB-alpha levels, as well as IL-1ss induced phosphorylation of NFkappaB, p38, and c-Jun-N-terminal kinase (JNK) MAPKs in HCEpiCs
Tewari et al., Arch Oral Biol 1996 (Periodontitis) : IL-1 induced the production of steady-state mRNA levels of I kappa B-alpha in the cultured fibroblasts
Bonizzi et al., Eur J Biochem 1996 : In these cells, IL-1 beta rapidly induces NF-kappa B through a complete degradation of I kappa B-alpha , while H2O2 activates NF-kappa B with slower kinetics through a partial degradation of I kappa B-alpha, p100 and p105
Bergmann et al., J Biol Chem 1998 : However, IL-1beta induced IkappaBalpha degradation as well as NF-kappaB nuclear translocation and DNA binding, as determined by Western blot and electro-mobility shift assay, respectively, are not affected by these inhibitors
Geleziunas et al., Mol Cell Biol 1998 (Cell Transformation, Viral...) : Our studies now demonstrate that HTLV-1 Tax activates the recently identified cellular kinases IkappaB kinase alpha (IKKalpha) and IKKbeta, which normally phosphorylate IkappaB alpha on both of its N-terminal regulatory serines in response to tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) stimulation