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SMAD7 — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Verrecchia et al., J Biol Chem 2000
:
Tumor necrosis factor-alpha inhibits transforming growth factor-beta
/Smad signaling in human dermal fibroblasts via AP-1 activation ... In this report, we demonstrate that
TNF-alpha prevents TGF-beta induced
Smad-specific gene transactivation without inducing detectable levels of inhibitory Smad7 in human dermal fibroblasts ... Expression of antisense c-Jun mRNA prevents
TNF-alpha inhibition of
TGF-beta/Smad signaling whereas that of dominant negative Ikappa-B kinase-alpha or antisense Smad7 does not
Lallemand et al., Oncogene 2001
:
In addition,
Smad7 inhibited
TNF-alpha stimulation of NF-kappaB and increased TNF-alpha mediated apoptosis in MDCK cells
Verrecchia et al., J Biol Chem 2003
:
We demonstrate that, in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ), interleukin-1 and
tumor necrosis factor-alpha (TNF-alpha) did not
inhibit the formation of SMAD-DNA complexes and the resulting
SMAD-driven transcription in response to TGF-beta
Ng et al., Kidney Int Suppl 2005
(Nephritis) :
Real-time polymerase chain reaction ( PCR ) and immunohistochemistry revealed that gene transfer of
Smad7 resulted in a substantial inhibition of interleukin-1beta (IL-1beta) and
tumor necrosis factor alpha (TNFalpha) expression ( all P < 0.01 vs. control )
Tzimas et al., Cell Signal 2006
:
Overexpression of USP31 in HEK 293T cells inhibited
TNFalpha , CD40, LMP1, TRAF2, TRAF6 and IKKbeta mediated NF-kappaB activation, but did not
inhibit Smad mediated transcription activation
Okabe et al., J Endod 2006
:
Furthermore, we examined the
effect of
TNF-alpha and PDTC on
Smad7 expression using RT-PCR and western blot analysis ...
Smad7 expression in HDP cells was
increased by
TNF-alpha , but decreased by PDTC treatment
Li et al., J Bone Miner Res 2007
(Osteoporosis) :
In vitro,
TNFalpha suppresses BMP-2- and TGFbeta mediated
Smad activation through induction of NF-kappaB ... In vitro,
TNFalpha potently
suppressed Smad signaling induced by TGFbeta and BMP-2, downregulated BMP-2 mediated Runx2 expression, and inhibited mineralization of osteoblasts
Yamaguchi et al., Int J Mol Med 2011
(Bone Resorption) :
Furthermore, vitamin K2 prevented
repression by
tumor necrosis factor a (TNFa) of
SMAD signaling induced by either transforming growth factor ß ( TGFß ) or bone morphogenetic protein-2 (BMP-2)