Gene interactions and pathways from curated databases and text-mining

◀ Back to TNF

SMAD7 — TNF

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Verrecchia et al., J Biol Chem 2000 : Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation ... In this report, we demonstrate that TNF-alpha prevents TGF-beta induced Smad-specific gene transactivation without inducing detectable levels of inhibitory Smad7 in human dermal fibroblasts ... Expression of antisense c-Jun mRNA prevents TNF-alpha inhibition of TGF-beta/Smad signaling whereas that of dominant negative Ikappa-B kinase-alpha or antisense Smad7 does not
Lallemand et al., Oncogene 2001 : In addition, Smad7 inhibited TNF-alpha stimulation of NF-kappaB and increased TNF-alpha mediated apoptosis in MDCK cells
Verrecchia et al., J Biol Chem 2003 : We demonstrate that, in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ), interleukin-1 and tumor necrosis factor-alpha (TNF-alpha) did not inhibit the formation of SMAD-DNA complexes and the resulting SMAD-driven transcription in response to TGF-beta
Ng et al., Kidney Int Suppl 2005 (Nephritis) : Real-time polymerase chain reaction ( PCR ) and immunohistochemistry revealed that gene transfer of Smad7 resulted in a substantial inhibition of interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) expression ( all P < 0.01 vs. control )
Tzimas et al., Cell Signal 2006 : Overexpression of USP31 in HEK 293T cells inhibited TNFalpha , CD40, LMP1, TRAF2, TRAF6 and IKKbeta mediated NF-kappaB activation, but did not inhibit Smad mediated transcription activation
Okabe et al., J Endod 2006 : Furthermore, we examined the effect of TNF-alpha and PDTC on Smad7 expression using RT-PCR and western blot analysis ... Smad7 expression in HDP cells was increased by TNF-alpha , but decreased by PDTC treatment
Li et al., J Bone Miner Res 2007 (Osteoporosis) : In vitro, TNFalpha suppresses BMP-2- and TGFbeta mediated Smad activation through induction of NF-kappaB ... In vitro, TNFalpha potently suppressed Smad signaling induced by TGFbeta and BMP-2, downregulated BMP-2 mediated Runx2 expression, and inhibited mineralization of osteoblasts
Yamaguchi et al., Int J Mol Med 2011 (Bone Resorption) : Furthermore, vitamin K2 prevented repression by tumor necrosis factor a (TNFa) of SMAD signaling induced by either transforming growth factor ß ( TGFß ) or bone morphogenetic protein-2 (BMP-2)