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IL4 — SOCS1

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → SOCS1 (SOCS1) (modification, collaborate) Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Obiri et al., J Biol Chem 1995, Murata et al., J Immunol 1996, Obiri et al., J Immunol 1997, Miloux et al., FEBS Lett 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL4-mediated signaling events: SOCS1 (SOCS1) → IL4/IL4R/JAK1/IL13RA1/JAK2 complex (IL4-IL4R-JAK1-IL13RA1-JAK2) (modification, inhibits)
  Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Obiri et al., J Biol Chem 1995, Murata et al., J Immunol 1996, Obiri et al., J Immunol 1997, Miloux et al., FEBS Lett 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → SOCS1 (SOCS1) (modification, collaborate) Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: SOCS1 (SOCS1) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, inhibits)
  Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
  Evidence: mutant phenotype, assay, physical interaction, other species

Text-mined interactions from Literome

Dickensheets et al., Proc Natl Acad Sci U S A 1999 (Translocation, Genetic) : Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression
Federici et al., J Immunol 2002 (Dermatitis, Allergic Contact...) : We show in this work that SOCS1, SOCS2, SOCS3, and cytokine-inducible SH2 containing protein mRNA were up-regulated by IFN-gamma in normal human keratinocytes, whereas only SOCS1 or SOCS1 and cytokine-inducible SH2 containing protein were induced by TNF-alpha or IL-4 , respectively
Cornish et al., J Biol Chem 2003 : SOCS-1 expression is induced by interleukin (IL) 2, IL-4 , IL-7, and IL-15, and SOCS-1-deficient T cells show increased proliferation and prolonged survival in response to IL-2 and IL-4
Hebenstreit et al., J Immunol 2003 : IL-4 and IL-13 induce SOCS-1 gene expression in A549 cells by three functional STAT6 binding motifs located upstream of the transcription initiation site ... We show here that SOCS-1 expression can be induced in the human epithelial lung cell line A549 by IL-4 and IL-13 ... STAT6 is therefore required for IL-4-IL-13 dependent SOCS-1 expression in A549 cells, and the three identified binding motifs cooperate to induce maximal transcription
Jackson et al., J Immunol 2004 : SOCS1 is primarily induced by IL-4 through a STAT1 dependent mechanism, whereas SOCS3 is induced mainly by GM-CSF
Travagli et al., J Biol Chem 2004 : Collectively, our data demonstrated the involvement of STAT6 and Ets, via a composite DNA element, in the IL-4 regulation of Socs-1 gene expression in keratinocytes
Yu et al., J Immunol 2004 : Surprisingly, IL-4 is a potent inducer of STAT1 activation in Th2 but not Th1 cells, and SOCS1 or SOCS3 expression is dramatically reduced in STAT1 ( -/- ) Th2 cells
Hebenstreit et al., Mol Immunol 2005 : SOCS-1 and SOCS-3 inhibit IL-4 and IL-13 induced activation of Eotaxin-3/CCL26 gene expression in HEK293 cells
Davey et al., Tissue Antigens 2006 : In addition, SOCS1 has a complex role in T cell activation, and studies have revealed significant roles for SOCS1 in the regulation of IL-4 , IL-12 and IL-15 in vivo
Dickensheets et al., Genes Immun 2007 : We found that IL-4 , like IFN-gamma, induces rapid de novo expression of SOCS-1 in primary macrophages ... Induction of SOCS-1 gene expression by IL-4 is STAT6 dependent, whereas induction of SOCS-1 by IFN-gamma is STAT1 dependent
Shoda et al., Biochem Biophys Res Commun 2007 (Pulmonary Fibrosis) : In contrast, IFN-gamma suppressed the increase of collagen production induced by IL-4 in wild type fibroblasts but not SOCS1-deficient fibroblasts, suggesting IFN-gamma acted exclusively via SOCS1 in this case
Albanesi et al., J Immunol 2007 : We further demonstrate that IL-4 and IL-13 activate STAT-6 and induce the suppressors of cytokine signaling (SOCS)-1 and -3
Woodward et al., Immunology 2010 : We investigated whether the early induction of SOCS1 by IL-4 was responsible for the suppression of LPS induced tumour necrosis factor (TNF)-alpha production by IL-4
Park et al., J Allergy Clin Immunol 2013 (Nasal Polyps...) : Nasal epithelial cell culture was used to elucidate the effect of IL-4 , IL-5, IL-6, IL-10, IL-13, IFN-?, TNF-a, and TGF-ß1 on SOCS1 and SOCS3 expression in sinus mucosa ... SOCS1 was induced by IL-4 , IL-13, IFN-?, and TNF-a, while SOCS3 expression was upregulated by IL-6, IL-13, IFN-?, and TNF-a