◀ Back to RAF1
PRKCA — RAF1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
RAF1
→
PRKCA
(increases, PRKCA Activity, RAF1 Activity)
Evidence: which are involved in cytokine signaling.86 Other Rasindependent activators of Raf include interferon beta, protein kinase C (PKC) alpha, antiapoptotic proteins (eg, Bcl-2), scaffolding proteins (eg, ceramide-activated protein kinase), ultraviolet light, ionizing radiation, retinoids, erythropoietin, and dimerization between Raf isoforms86-94 (Fig 3).
-
BioCarta signaling pathway from g-protein families:
PKC (PRKCA/PRKCB1)
→
RAF1
(modification, activates)
-
KEGG Vascular smooth muscle contraction:
PRKCA/PRKCB/PRKCD/PRKCE/PRKCG/PRKCH/PRKCQ
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG VEGF signaling pathway:
PRKCA/PRKCB/PRKCG
→
RAF1
(protein-protein, activation)
-
KEGG MAPK signaling pathway:
PRKCA/PRKCB/PRKCG
→
RAF1
(protein-protein, phosphorylation)
-
KEGG GnRH signaling pathway:
PRKCA/PRKCB/PRKCD
→
RAF1
(protein-protein, activation)
-
KEGG Influenza A:
PRKCA
→
RAF1
(protein-protein, activation)
-
KEGG Pathways in cancer:
PRKCA/PRKCB/PRKCG
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
KEGG Non-small cell lung cancer:
PRKCA/PRKCB/PRKCG
→
ARAF/BRAF/RAF1
(protein-protein, activation)
-
WikiPathways Endothelin Pathways:
PRKCA
→
RAF1
(mim-stimulation)
-
WikiPathways Signaling Pathways in Glioblastoma:
PRKCZ/PRKCQ/PRKCH/PRKCG/PRKCD/PRKCI/PRKCB/PRKCA
→
ARAF/BRAF/RAF1
(mim-stimulation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ibitayo et al., Am J Physiol 1999
:
Our results indicate that 1 ) translocation of
Raf-1 to the membrane when stimulated with ceramide is inhibited by vasoactive intestinal peptide (VIP), a relaxant neuropeptide ; 2 ) PKC-alpha and mitogen activated protein kinase translocate and colocalize on the membrane in response to ceramide, and
PKC-alpha translocation is
inhibited by VIP ; 3 ) HSP27 colocalizes with actin when contraction occurs ; and 4 ) HSP27 immunoprecipitates with actin and with the contractile proteins myosin, tropomyosin, and caldesmon
Buitrago et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Activation of
RAF-1 through Ras and
protein kinase Calpha mediates 1alpha,25 ( OH ) 2-vitamin D3 regulation of the mitogen activated protein kinase pathway in muscle cells
Dreikhausen et al., Int Immunol 2003
:
Inhibition of the synthesis of
PKCalpha and beta by specific phosphorothioate modified antisense oligonucleotides ( ODN )
resulted in suppression of phosphorylation and activation of
Raf-1 , mitogen activated extracellular regulated kinase kinases and extracellular regulated kinases in stimulated Jurkat T cells
Clark et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
PKC/PKC alpha activity
promoted GTP loading of Ras, activation of
Raf-1 , and phosphorylation/activation of ERK
Chang et al., Pharmacol Res 2009
:
YC-1 mediated
Raf-1 activation was
inhibited by an sGC inhibitor ( ODQ ), a PKG inhibitor ( KT-5823 ), a Ras inhibitor ( manumycin A ), a dominant negative Ras mutant ( RasN17 ), a
protein kinase C-alpha (PKC-alpha) inhibitor ( Ro 32-0432 ), and a phosphoinositide-3-OH-kinase (PI3K) inhibitor ( LY 294002 ) ... Moreover,
PKC-alpha and PI3K signal might be
involved in YC-1 induced
Raf-1 activation
Häfner et al., Mol Cell Biol 1994
(Cell Transformation, Neoplastic) :
Phosphorylation by PKA interferes with the
activation of
Raf-1 by either
PKC alpha or the tyrosine kinase Lck and even can downregulate the kinase activity of Raf-1 previously activated by PKC alpha or amino-terminal truncation
Kolch et al., Nature 1993
(Cell Transformation, Neoplastic) :
Here we investigate the molecular mechanism and biological consequences of
PKC alpha mediated
Raf-1 activation in NIH3T3 fibroblasts ...
PKC alpha directly phosphorylates and
activates Raf-1 both in vitro and in vivo ...
PKC alpha induces
Raf-1 phosphorylation at several sites, including a serine residue at position 499
Yu et al., Mol Pharmacol 1996
:
These results demonstrate that ATP induced
Raf-1 and MAPK activations
involve the activation of
PKC-alpha and PKC-delta
Schönwasser et al., Mol Cell Biol 1998
:
Stimulation of
c-Raf1 by
PKC-alpha and PKC-eta was abrogated for RafCAAX, which is a membrane localized, partially active form of c-Raf1