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FAS — MAP3K5

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of MAP3K5-QARS → FAS (decreases, MAP3K5/QARS Activity) Ko et al., J Biol Chem 2001*
  Evidence: we investigated the molecular interaction between human glutaminyl-tRNA synthetase (QRS) and ASK1 and found the Gln-dependent association of the two molecules. While their association was enhanced by the elevation of Gln concentration, they were dissociated by Fas ligation within 5 min. The association involved the catalytic domains of the two enzymes. The ASK1 activity was inhibited by the interaction with QRS as determined by in vitro kinase and transcription assays. Finally, we have shown tha...
• BioCarta keratinocyte differentiation: FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5) → JNKK1 (MAP2K4) (modification, activates)
• BioCarta hiv-1 nef: negative effector of fas and tnf: FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG) → Caspase 8/Caspase 8/Caspase 8/Caspase 8 complex (CASP8) (modification, activates)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG) → I-FLICE (CFLAR) (modification, activates)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNFSF6 (FASLG) → FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNFSF6 (FASLG) → FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8) → FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG) (modification, collaborate)
  
• BioCarta keratinocyte differentiation: FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5) → MEK3 (MAP2K3) (modification, activates)
• BioCarta keratinocyte differentiation: FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5) → MEK6 (MAP2K6) (modification, activates)
• BioCarta keratinocyte differentiation: FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5) → FAS L/FAS/DAXX complex (FASLG-FAS-DAXX) (modification, collaborate)
  
• BioCarta keratinocyte differentiation: FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5) → ASK1 (MAP3K5) (modification, collaborate)
• BioCarta keratinocyte differentiation: FAS L/FAS/DAXX complex (FASLG-FAS-DAXX) → ASK1 (MAP3K5) (modification, collaborate)
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD) (modification, activates)
  Micheau et al., Cell 2003, Yang et al., Cell 1997, Saitoh et al., EMBO J 1998, Chang et al., Science 1998
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: FASLG (FASLG) → FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8) (modification, collaborate)
  Juo et al., Curr Biol 1998
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: FASLG (FASLG) → FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD) (modification, collaborate)
  Juo et al., Curr Biol 1998
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8) → FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD) (modification, collaborate)
  Juo et al., Curr Biol 1998
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: c-FLIP (CFLAR) → FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD) (modification, inhibits)
  Medema et al., EMBO J 1997
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD) → Caspase 8 (4 units) complex (CASP8) (modification, activates)
  Medema et al., EMBO J 1997

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAP3K5 — FAS (physical association, affinity chromatography technology) Ko et al., J Biol Chem 2001*
• IRef Intact Interaction: MAP3K5 — FAS (physical association, anti bait coimmunoprecipitation) Ko et al., J Biol Chem 2001*

Text-mined interactions from Literome

Charette et al., Ann N Y Acad Sci 2000 : Fas also activates a caspase independent pathway which correlates with Fas induced translocation of Daxx from the nucleus to the cytoplasm and involves the interaction of Daxx with Fas and Ask1
Yang et al., Mol Cells 2002 (Disease Models, Animal...) : In addition, core protein blocked the Fas mediated activation of apoptosis signal regulating kinase 1 ( ASK1 ), a major upstream MAPKKK of p38