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E2F1 — EPHB2

Text-mined interactions from Literome

Grewal et al., J Biol Chem 2001 : This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and ERK and activation of cAMP-responsive element binding protein ( CREB ), NF-kappaB, and E2F ), as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs
Wu et al., Oncogene 2007 (Breast Neoplasms) : Moreover, endogenous E2F-1 upregulates PAC1 and suppresses ERK activity, leading to cell death in response to 4-HPR
Korotayev et al., Cell Signal 2008 (MAP Kinase Signaling System) : ERK activation is regulated by E2F1 and is essential for E2F1 induced S phase entry ... We demonstrate that E2F1 induces ERK activation via a transcriptional mechanism and upregulates the expression of two guanine nucleotide exchange factors, RASGRP1 and RASGEF1B, which promote Ras activation ... Furthermore, we show that E2F1 induced ERK activity is essential for E2F1 induced S phase entry
Fang et al., Cell Immunol 2009 : ERK1/2 activation leads to the release of E2F that could bind to the E2F binding sites in the inverted CCAAT box binding protein ( ICBP90 ) gene promoter
Hong et al., Exp Cell Res 2011 (Prostatic Neoplasms) : Ectopic expression of a constitutively active AR inhibited Raf/MEK/ERK mediated regulation of the differentiation markers, neuron-specific enolase and neutral endopeptidase, and the cyclin dependent kinase inhibitors, p16(INK4A) and p21 ( CIP1 ), but not Rb phosphorylation and E2F1 expression, indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling
Paquin et al., BMC cell biology 2013 (Adenoma...) : Treatment of quiescent HIEC with serum induced ERK1/2 activation, E2F4 phosphorylation, E2F4 nuclear translocation and G1/S phase transition while inhibition of MEK/ERK signaling by U0126 prevented these events