◀ Back to MYC

FBXW7 — MYC

Pathways - manually collected, often from reviews:

• NCI Pathway Database C-MYC pathway: Fbw7-gamma (FBXW7) → MYC/Max complex (MYC-MAX) (modification, activates) Yada et al., EMBO J 2004, Welcker et al., Proc Natl Acad Sci U S A 2004*
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: MYC — FBXW7 (affinity chromatography technology) Wei et al., Cancer Cell 2005*
• IRef Bind_translation Interaction: FBXW7 — MYC (affinity chromatography technology) Wei et al., Cancer Cell 2005*
• IRef Biogrid Interaction: MYC — FBXW7 (direct interaction, enzymatic study) Yada et al., EMBO J 2004
• IRef Biogrid Interaction: MYC — FBXW7 (direct interaction, pull down) Yada et al., EMBO J 2004
• IRef Biogrid Interaction: MYC — FBXW7 (physical association, affinity chromatography technology) Koch et al., Cell cycle (Georgetown, Tex.) 2007
• IRef Biogrid Interaction: MYC — FBXW7 (physical association, affinity chromatography technology) Kim et al., FEBS Lett 2010*
• IRef Biogrid Interaction: MYC — FBXW7 (direct interaction, pull down) Cho et al., Mol Cells 2010*
• IRef Biogrid Interaction: MYC — FBXW7 (physical association, affinity chromatography technology) Popov et al., Cell cycle (Georgetown, Tex.) 2007
• IRef Biogrid Interaction: MYC — FBXW7 (physical association, affinity chromatography technology) Fujii et al., Mol Cell 2006*
• IRef Biogrid Interaction: MYC — FBXW7 (physical association, affinity chromatography technology) Thompson et al., J Exp Med 2007*
• IRef Biogrid Interaction: MYC — FBXW7 (physical association, affinity chromatography technology) Welcker et al., Curr Biol 2004*
• IRef Biogrid Interaction: MYC — FBXW7 (physical association, affinity chromatography technology) Welcker et al., Proc Natl Acad Sci U S A 2004*
• IRef Biogrid Interaction: MYC — FBXW7 (physical association, affinity chromatography technology) Yada et al., EMBO J 2004
• IRef Hprd Interaction: MYC — FBXW7 (in vivo) Wei et al., Cancer Cell 2005*, Fujii et al., Mol Cell 2006*
• IRef Intact Interaction: Complex of 222 proteins (association, tandem affinity purification) Koch et al., Cell cycle (Georgetown, Tex.) 2007
• IRef Intact Interaction: MYC — FBXW7 (physical association, anti bait coimmunoprecipitation) Fujii et al., Mol Cell 2006*

Text-mined interactions from Literome

Fujii et al., Cancer Sci 2006 (Breast Neoplasms) : Fbxw7 contributes to the ubiquitin mediated degradation of cyclin E, c-Myc , Aurora-A, Notch and c-Jun, all of which appear to function as cell-cycle promoters and oncogenic proteins ... Forced expression of Fbxw7 reduced the levels of cyclin E, c-Myc and Aurora-A in the Fbxw7-mutant cells
Guo et al., Biochem Biophys Res Commun 2012 (Colorectal Neoplasms) : Rictor regulates FBXW7 dependent c-Myc and cyclin E degradation in colorectal cancer cells ... Genetic knockout of FBXW7 blunts the effects of rictor, suggesting that rictor regulation of c-Myc and cyclin E requires FBXW7
Okita et al., Genes Cells 2012 : Among these factors, the abundance of c-Myc is strictly regulated by Fbxw7 , a subunit of Skp1-Cul1-F-box protein-type ubiquitin ligase
Tu et al., PloS one 2013 : Here, we suggest that the activation of Fbxw7 by adenoviral delivery of p53 leads to increased proteasomal degradation of c-Myc and cyclin E enabling growth arrest and apoptosis