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HAUS8 — PLK1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 26 proteins (physical association, tandem affinity purification) Hutchins et al., Science 2010

Text-mined interactions from Literome

Lawo et al., Curr Biol 2009 : HAUS , the 8-subunit human Augmin complex, regulates centrosome and spindle integrity
Johmura et al., Proc Natl Acad Sci U S A 2011 : Loss of either the Nedd1 S460 function or the Plk1 dependent Hice1 phosphorylation impaired both the Augmin-MT interaction and ?-tubulin recruitment to the spindles, thus resulting in improper bipolar spindle formation that ultimately leads to mitotic arrest and apoptotic cell death