Hu et al., Mol Biol Cell 2005
:
Furthermore, in response to H2O2, inhibition of ERK activation repressed p66shcA dependent phosphorylation of FOXO3a and the down-regulation of its target gene p27kip1
Yang et al., Nat Cell Biol 2008
(Breast Neoplasms...) :
Taken together, our study elucidates a novel pathway in cell growth and tumorigenesis through negative regulation of FOXO3a by RAS-ERK and MDM2