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GSK3B — VEGFA
Text-mined interactions from Literome
Guo et al., Stroke 2009
:
In contrast, neither inhibition of
GSK-3beta nor inhibition of PI3-K
had any detectable effects on
VEGF levels in astrocytes
Steindl-Kuscher et al., Invest Ophthalmol Vis Sci 2009
:
VEGF , on the other hand,
led to a reduction in cyclin D1 and to an increase in
GSK 3beta and beta-catenin expression which was paralleled by an increase in RPE-specific differentiation markers
Maes et al., EMBO J 2010
:
Genetic and pharmacological interventions showed that
VEGF increased bone mass through a VEGF receptor 2- and phosphatidyl inositol 3-kinase mediated pathway inducing beta-catenin transcriptional activity in endothelial and osteoblastic cells, likely through modulation of
glycogen synthase kinase 3-beta phosphorylation
Yang et al., Invest Ophthalmol Vis Sci 2010
:
PEDF blocked
VEGF induced phosphorylation of extracellular signal regulated kinase ( ERK ), p38 MAP kinase, the p38 substrate MAP kinase activated protein kinase-2 ( MAPKAPK-2 ), and
GSK3-beta , but it had no effect on the phosphorylation of VEGFR2