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SMAD4 — STK11

Pathways - manually collected, often from reviews:

• NCI Pathway Database LKB1 signaling events: LIP1/LKB1/SMAD4 complex (STK11IP-STK11-SMAD4) → SMAD4 (SMAD4) (modification, collaborate) Smith et al., Hum Mol Genet 2001*
  Evidence: physical interaction
• NCI Pathway Database LKB1 signaling events: LIP1/LKB1/SMAD4 complex (STK11IP-STK11-SMAD4) → LIP1 (STK11IP) (modification, collaborate) Smith et al., Hum Mol Genet 2001*
  Evidence: physical interaction
• NCI Pathway Database LKB1 signaling events: LIP1/LKB1/SMAD4 complex (STK11IP-STK11-SMAD4) → LKB1 (STK11) (modification, collaborate) Smith et al., Hum Mol Genet 2001*
  Evidence: physical interaction
• NCI Pathway Database LKB1 signaling events: SMAD4 (SMAD4) → LKB1 (STK11) (modification, collaborate) Smith et al., Hum Mol Genet 2001*
  Evidence: physical interaction

Text-mined interactions from Literome

Raftery et al., Dev Biol 1999 : Work in mammalian tissue culture has elucidated a biochemical model for signal transduction, in which activation of receptor serine-threonine kinase activity leads to phosphorylation of specific Smad proteins and translocation of heteromeric Smad protein complexes to the nucleus
Morén et al., J Biol Chem 2011 : LKB1 inhibits Smad4 from binding to either TGFß- or bone morphogenetic protein-specific promoter sequences, which correlates with the negative regulatory effect LKB1 exerts on Smad4 dependent transcription