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IL6 — S100A9

Text-mined interactions from Literome

Jacobs et al., Skin Pharmacol Physiol 2004 (Warts) : Analysis of imiquimod treated warts demonstrated that imiquimod enhanced IL-6 expression and induced IL-8, GM-CSF, MRP-8 and MRP-14
Schelbergen et al., Arthritis Rheum 2012 (Osteoarthritis) : Stimulation of chondrocytes with S100A8 and S100A9 caused a strong up-regulation of catabolic markers ( MMPs 1, 3, 9, and 13, interleukin-6 [ IL-6 ], IL-8, and monocyte chemotactic protein 1 ) and down-regulation of anabolic markers ( aggrecan and type II collagen ), thereby favoring cartilage breakdown
Abbas et al., Stroke 2012 (Carotid Artery Diseases...) : Our main findings were : ( 1 ) plasma levels of S100A12 were significantly higher in patients with carotid atherosclerosis compared with healthy control subjects with the highest levels in patients with the most recent symptoms ( ie, within 2 months ) ; ( 2 ) plasma levels of S100A8/S100A9 showed a modest increase in patients with symptoms in the previous 2 to 6 months but not in the other patients ; ( 3 ) mRNA levels of S100A8, S100A9, and S100A12 showed increased expression in atherosclerotic carotid plaques from patients with the most recent symptoms compared with the remaining patients ; ( 4 ) in THP-1 monocytes, activation of Toll-like receptors 2 and 4 increased mRNA levels of S100A8, S100A9 , and S10012 and interleukin-1ß , interferon ?, and releasate from thrombin activated platelets significantly enhanced the expression of S100A12
Lee et al., PloS one 2012 (Colitis, Ulcerative...) : Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis ... We investigated the role of IL-6 in S100A9 expression in CECs using a colitis model