Liao et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
Using this reporter assay, we have demonstrated that interferon-gamma, interleukin-1beta, and tumor necrosis factor-alpha can specifically stimulate gamma-secretase activity, concomitant with increased production of Abeta and the intracellular domain of APP ( AICD )
Kuo et al., Mol Biol Cell 2008
:
Our previous results showed that tumor necrosis factor-alpha (TNF-alpha) can potently stimulate gamma-secretase activity through a c-Jun N-terminal kinase (JNK) dependent pathway