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FOXO3 — IFI27
Text-mined interactions from Literome
Dijkers et al., Mol Cell Biol 2000
:
Tamoxifen mediated activation of
FKHR-L1 ( A3 ) : ER*
resulted in a striking increase in
p27 ( KIP1 ) promoter activity and mRNA and protein levels as well as induction of the apoptotic program
Stahl et al., J Immunol 2002
:
Indeed, active
FoxO3 can
induce expression of IL-2 regulated genes, such as the cdk inhibitor
p27 ( Kip1 ) and the proapoptotic Bcl-2 family member Bim
Park et al., Arterioscler Thromb Vasc Biol 2005
(Hyperplasia) :
In vivo, the phosphorylation of
FKHRL1 increased significantly 3 hours after balloon injury and decreased thereafter, with the subsequent downregulation of
p27
Abid et al., J Biol Chem 2005
(Hyperplasia) :
In a rat balloon carotid arterial injury model, adenovirus mediated gene transfer of
FKHRL1 caused an increase in the expression of
p27 ( kip1 ) in the VSMC and inhibition of neointimal hyperplasia
Chandramohan et al., J Cell Biochem 2008
(Neoplasms) :
The inhibition of
FOXO3a mediated activation of the
p27 gene by the high aberrant expression of c-Myc in many tumor cells likely contributes to their uncontrolled proliferation and invasive phenotype
Lees et al., Am J Physiol Cell Physiol 2008
:
Previously, we have demonstrated that
forkhead box O3a (FOXO3a) overexpression
increased p27 ( Kip1 ) promoter activity and protein expression, whereas it decreased proliferation in muscle precursor cells ( MPCs ) ... Interestingly, MPCs isolated from old animals exhibited an increased
FOXO3a induced
p27 ( Kip1 ) promoter activity compared with MPCs isolated from young animals ... Deletion of a 253-bp portion of the 5'-untranslated region ( UTR ) resulted in a significant decrease in
FOXO induced
p27 ( Kip1 ) promoter expression ... Site-specific mutation of a daf-16 family protein binding element ( DBE ) within this 253-bp portion of the 5'-UTR also demonstrated a decrease in
FOXO induced
p27 ( Kip1 ) promoter expression
Essaghir et al., J Biol Chem 2009
:
Conversely, ectopic
FOXO3 activation blocked the proliferation of fibroblasts and
induced the expression of FOXO1, FOXO4, and
p27-KIP1
Gopinath et al., Mol Oncol 2011
(Glioma) :
uPAR and cathepsin B downregulation was recently shown to
induce p27 expression through
PI3K/Akt/FOXO3a signaling