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CTNNB1 — STK11
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CTNNB1
→
STK11
(decreases, STK11 Activity)
Evidence: other studies have indicated that Lkb1 downregulates the b-catenin pathway through either activation of GSK3—a negative regulator of b-catenin—or through diverting MARK2/ Par1a from its capacity to activate the pathway (Spicer et al., 2003; Lin-Marq et al., 2005).
Text-mined interactions from Literome
Ossipova et al., Nat Cell Biol 2003
:
These studies show that
LKB1/XEEK1 is
required for
Wnt-beta-catenin signalling in frogs and mammals and provides novel insights into its role in vertebrate developmental patterning and carcinogenesis
Ma et al., Oncol Rep 2010
(Adenocarcinoma...) :
These findings suggest that Wnt signaling may be activated in a subset of PJSs, and activation of the
Wnt/beta-catenin signaling in PJS polyps may be
caused by
LKB1 expression