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SYK — TNF

Text-mined interactions from Literome

Lin et al., J Immunol 2000 : Further analysis of kinase dependence using antisense to Syk kinase demonstrated that TNF , but not IL-1 beta, stimulation by CD8 alpha is Syk dependent
Takada et al., J Immunol 2004 : Whether Syk plays any role in TNF signaling was investigated ... TNF also activated Syk in myeloid and epithelial cells ... TNF induced Syk activation was abolished by piceatannol ( Syk-selective inhibitor ), which led to the suppression of TNF induced activation of c- JNK, p38 MAPK, and p44/p42 MAPK ... Jurkat cells that did not express Syk ( JCaM1, JCaM1/lck ) showed lack of TNF induced Syk , JNK, p38 MAPK, and p44/p42 MAPK activation, as well as TNF induced IkappaBalpha phosphorylation, IkappaBalpha degradation, and NF-kappaB activation ... Immunoprecipitation of cells with Syk Abs showed TNF dependent association of Syk with both TNFR1 and TNFR2 ; this association was enhanced by up-regulation of Syk expression with Syk-cDNA and suppressed by down-regulation of Syk using siRNA-Syk
Han et al., J Leukoc Biol 2006 : However, their differential effects on cell spreading, bacteria induced RB, TNF induced degranulation, TNF induced protein tyrosine phosphorylation, and TNF induced Syk activation suggested that each may act on different elements of neutrophil signaling pathways
Zhou et al., Oncogene 2009 (Breast Neoplasms) : Syk enhances the activation of nuclear factor-kappaB by TNF and this is antagonized by TRIP
Skrzypek et al., Microbes Infect 2009 : Indeed, specific Syk inhibition significantly suppressed the production of IL-12, IL-6, and TNF-alpha
Guo et al., Int Immunopharmacol 2009 (Carcinoma, Lewis Lung) : It was an effective inducer of MAPKs- and Syk dependent TNF-alpha and IL-6 secretion in murine resident peritoneal macrophages
Fang et al., Glycoconj J 2012 (Sarcoma) : It induced TNF-a and IL-6 production and the activation of Syk and NF-?B signaling in resident peritoneal macrophages from ICR mice, which could be significantly inhibited by the blocking reagent laminarin ... The TNF-a secretion and activation of Syk/NF-?B signaling triggered by GFPBW1 were enhanced in RAW264.7 cells overexpressing wild but not mutant ( d38 and Y15S ) Dectin-1
Koo et al., Cell Biol Int 2013 : TNF-a increased tyrosine phosphorylation of Syk , which was attenuated by NAC and MPA
Zheng et al., Exp Cell Res 2013 : TMP significantly inhibited TNF-a induced phosphorylation of Syk and PI3K