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CTNNB1 — RAD17
Text-mined interactions from Literome
Shekhar et al., Mol Cancer Res 2006
(Breast Neoplasms...) :
Essential
role of T-cell
factor/beta-catenin in regulation of
Rad6B : a potential mechanism for Rad6B overexpression in breast cancer cells ... Derepression and activation of
Rad6B promoter in MCF10A cells
require coexpression of
beta-catenin and p300
Shekhar et al., Cancer Res 2008
(Breast Neoplasms) :
Here, we show that forced
Rad6B overexpression in MCF10A breast cells
induces beta-catenin accumulation, which despite being ubiquitinated is stable and transcriptionally active ... A similar relationship between Rad6B, beta-catenin ubiquitination, and transcriptional activity was found in WS-15 and MDA-MB-231 breast cancer cells, and mouse mammary tumor virus-Wnt-1 mammary tumor derived cells, implicating
Rad6B in physiologic
regulation of
beta-catenin stability and activity