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AKT1 — E2F1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of E2F1-TOPBP1 → AKT1 (increases, E2F1/TOPBP1 Activity) Liu et al., EMBO J 2006*
  Evidence: We now show that the regulation of E2F1 by TopBP1 involves the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway, and is independent of pocket proteins. Akt phosphorylates TopBP1 in vitro and in vivo.... The Akt-dependent oligomerization is crucial for TopBP1 to interact with and repress E2F1.
• BioCarta il-2 receptor beta chain in t cell activation: RB/E2F-1 complex (E2F1-RB1) → AKT (AKT1) (modification, collaborate)

Text-mined interactions from Literome

Gille et al., J Biol Chem 1999 : Activated PI 3-kinase induces cyclin D(1) transcription and E2F activity, at least in part mediated by the serine/threonine kinase Akt/PKB , and to a lesser extent the Rho family GTPase Rac ... Activated PI 3-kinase induces cyclin D(1) transcription and E2F activity, at least in part mediated by the serine/threonine kinase Akt/PKB , and to a lesser extent the Rho family GTPase Rac
Berkovich et al., J Biol Chem 2001 (Cell Transformation, Neoplastic) : This Ras induced increase in E2F-1 levels is dependent on both MEK and PKB , and it is retinoblastoma independent
Chaussepied et al., Mol Cell 2004 : Transcriptional regulation of AKT activation by E2F ... We identify the adaptor protein Grb2 associated binder 2 (Gab2) as a direct E2F target gene and an essential effector of E2F dependent AKT activation
Yin et al., Prostate 2009 (Prostatic Neoplasms) : In prostate cancer C/EBPalpha promotes cell growth by the loss of interactions with CDK2, CDK4, and E2F and by activation of AKT
Lee et al., Oncogene 2009 (Prostatic Neoplasms) : MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1 mediated suppression of Akt phosphorylation ... After overexpressing of miR-330 in PC-3 cells, cell growth was suppressed by reducing E2F1 mediated Akt phosphorylation and thereby inducing apoptosis ... Collectively, this is the first study to show that E2F1 is negatively regulated by miR-330 and also show that miR-330 induces apoptosis in prostate cancer cells through E2F1 mediated suppression of Akt phosphorylation
Dar et al., J Biol Chem 2011 (Melanoma...) : The proliferative capacity of melanoma cells was suppressed by miR-205 and mediated by E2F regulated AKT phosphorylation
Brennan et al., Immunity 1997 : The expression of an active PKB is sufficient to induce E2F activity