◀ Back to FGF21
FGF1 — FGF21
Text-mined interactions from Literome
Crumley et al., Oncogene 1991
:
High-affinity binding and
activation of a truncated
FGF receptor by both
aFGF and bFGF
Kurosu et al., J Biol Chem 2007
:
Accordingly, FGF19, but not
FGF21 ,
activates FGF signaling in hepatocytes that primarily express FGFR4 and reduces transcription of CYP7A1 that encodes the rate limiting enzyme for bile acid synthesis
Kharitonenkov et al., J Cell Physiol 2008
:
Interestingly,
FGF-21 mediated effects are heparin independent suggesting that betaKlotho plays a role in
FGF-21 activity similar to the one played by heparin in the signaling of conventional FGFs
Yamamoto et al., J Biol Chem 2008
:
PDGF-AA induced the expression of the
fibroblast growth factor genes Fgf3 and -7, and PDGF-BB
induced the expression of
Fgf1 , -3, -7, and -10, whereas short interfering RNA for Pdgfa and Pdgfb inhibited the expression of Fgf3, -7, and -10, indicating that PDGFs regulate Fgf gene expression in SMG mesenchyme
Lü et al., Chin Med J (Engl) 2010
(Coronary Artery Disease) :
Furthermore,
FGF21 levels increased by 200 µmol/L bezafibrate could reduce CMECs apoptosis, and
inhibit FGF21 expression by shRNA induced apoptosis ( P < 0.05 )
Adams et al., PloS one 2012
:
The scaffold protein ßklotho ( KLB ) has previously been demonstrated in vitro to function as a co-factor permitting
FGF21 mediated
FGF receptor activation
Mori et al., PloS one 2013
(Colonic Neoplasms...) :
R50E is defective in inducing ternary complex formation, cell proliferation, and cell migration, and suppresses
FGF signaling
induced by WT
FGF1 ( a dominant negative effect ) in vitro
Relf et al., Cancer Res 1997
(Breast Neoplasms...) :
Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic
fibroblast growth factor , tumor growth factor beta-1, platelet
derived endothelial cell growth factor , placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
Zuber et al., J Cell Physiol 1997
:
Cysteine-rich
FGF receptor
regulates intracellular
FGF-1 and FGF-2 levels
Guillonneau et al., Growth Factors 1998
:
In addition,
FGF2 stimulated release of endogenous
FGF1 is associated with reduced apoptosis in RPE cells ... In addition,
FGF2 stimulated the production and release of phosphorylated
FGF1 by RPE cells
Klingenberg et al., J Biol Chem 1998
:
The
aFGF ( K132E ) mutant binds to and
activates fibroblast growth factor receptors equally strongly as the wild-type, but it is a poor mitogen