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FGF21 — FGF3
Text-mined interactions from Literome
Wilson et al., Curr Biol 2000
:
Fgf3 was also found to be expressed in the early epiblast, and ongoing
FGF signalling in epiblast cells was
required for acquisition of neural fate and for the suppression of Bmp4 and Bmp7 expression
Kurosu et al., J Biol Chem 2007
:
Accordingly, FGF19, but not
FGF21 ,
activates FGF signaling in hepatocytes that primarily express FGFR4 and reduces transcription of CYP7A1 that encodes the rate limiting enzyme for bile acid synthesis
Kharitonenkov et al., J Cell Physiol 2008
:
Interestingly,
FGF-21 mediated effects are heparin independent suggesting that betaKlotho plays a role in
FGF-21 activity similar to the one played by heparin in the signaling of conventional FGFs
Pearson et al., Development 2011
:
We show that collar cells are composed of
Fgf3 ( + ) SOX3 ( + ) proliferating progenitors, the induction of which is SHH dependent, but the maintenance of which
requires FGF signalling
Lü et al., Chin Med J (Engl) 2010
(Coronary Artery Disease) :
Furthermore,
FGF21 levels increased by 200 µmol/L bezafibrate could reduce CMECs apoptosis, and
inhibit FGF21 expression by shRNA induced apoptosis ( P < 0.05 )
Vendrell et al., Mech Dev 2013
(Wnt Signaling Pathway) :
Interestingly however, Wnt8a and
Fgf3 are redundantly
required for expression of
Fgf15 in the hindbrain indicating additional reciprocal interactions between Fgf and Wnt signalling
Adams et al., PloS one 2012
:
The scaffold protein ßklotho ( KLB ) has previously been demonstrated in vitro to function as a co-factor permitting
FGF21 mediated
FGF receptor activation