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GATA4 — GDF15

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Wang et al., Medical & biological engineering & computing 2009 : Furthermore, NRG-1 up-regulated the expression of the cardiac restricted transcription factors Nkx2.5 and GATA-4 and factors involved in differentiated cardiac cells ( alpha-MHC, beta-MHC and alpha-actinin ) ; NRG-1 induced increase of Nkx2.5 transcription was inhibited by treatment with the PI3 K inhibitor or ErbB receptor inhibitor
Chen et al., Mol Cell Biochem 2013 : This study showed that NRG-1ß significantly increased the percentage of beating embryoid bodies ( EBs ) and up-regulated the gene expressions of Nkx2.5, GATA4 , a-actin, MLC-2v, and ANF in a time dependent manner, with no effect on the gene expressions of HCN4 and Tbx3