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EPHB2 — PRR5

Text-mined interactions from Literome

Chen et al., Mol Carcinog 2010 (Neoplasms) : In this report, we focused on studying the role of mTORC1 and mTORC2 in rapamycin mediated Akt and ERK phosphorylation, and the antitumor effect of rapamycin in cancer cells in combination with Akt and ERK inhibitors ... Collectively, we conclude that mTORC2 plays a much more important role than mTORC1 in rapamycin mediated phosphorylation of Akt and ERK , and cotargeting AKT and ERK signaling may be a new strategy for enhancing the efficacy of rapamycin based therapeutic approaches in cancer cells
Cheng et al., Zhonghua Yan Ke Za Zhi 2011 (Disease Models, Animal...) : PRR siRNA could obviously reduce PRR expression, inhibit ERK1/2 signal transduction passageway activation, and diminish retinal neovascularization