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CD14 — IL6
Text-mined interactions from Literome
Hiraoka et al., Oral Microbiol Immunol 1998
(Gingivitis) :
To clarify the mechanism of the lipopolysaccharide induced modulation of the function of gingival fibroblasts, we investigated the
effect of
anti-CD14 on
interleukin 6 (IL-6) production on human gingival fibroblasts in vitro
Iwagaki et al., Infect Immun 2000
:
The purpose of this study was to compare and contrast the endotoxin neutralizing activities of two synthetic antiendotoxin peptides ( SAEP-2 and SAEP-4 ), PMB, and an LPS core-specific monoclonal antibody ( MAb ), WN1 222-5, based on their abilities to inhibit
CD14 mediated target cell uptake of fluorescein isothiocyanate ( FITC ) -conjugated LPS, detected by flow cytometry and confocal microscopy, and LPS induced production of the proinflammatory cytokines,
interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), as measured by bioassays
Tokuda et al., J Endod 2001
(Pulpitis) :
These results suggest the
IL-6 expression by pulp cell cultures is
CD14 dependent and regulated at the transcriptional level, and a combined treatment with immunoregulatory cytokines may be effective for control of pulpal inflammation due to P. intermedia LPS
Moesby et al., Eur J Pharm Sci 2003
:
Furthermore the
involvement of
CD14 in activation of
interleukin-6 release is investigated
Blais et al., Invest Ophthalmol Vis Sci 2005
:
In a dose-dependant manner, tear
CD14 and LBP
mediated the secretion of
interleukin (IL)-6 and IL-8 by corneal epithelia cells when challenged with LPS
Yu et al., Cell Immunol 2006
:
We found that
Hyper-IL-6 promoted the generation of CD15 ( + ) granulocytic and
CD14 ( + ) monocytic cells and suppressed that of CD14 ( - ) CD1a ( + ) dendritic cells from CD36 ( - ) CD15 ( - ) CD14 ( - ) CD1a ( - ) IL-6R ( + ) myeloid progenitors
Ruppert et al., Immunobiology 1991
:
In this study we compared the
effects of the cytokines IL-1,
IL-6 , IL-4, and a combination of IL-1 and IL-6 on the expression of the
CD14 antigen , the FcIIIg receptor molecule CD16 and the MHC-class II molecules HLA-DR and HLA-DP
Ikewaki et al., Tissue Antigens 1991
(Lymphoma, Large B-Cell, Diffuse) :
These findings suggest that the expression of
CD14 antigen on the surface of U937 cells cultured with formalin killed Gram negative bacteria is
induced by
interleukin-6 and can be explained on the basis of the autocrine mechanism of interleukin-6
Yamamura et al., Cancer Sci 2007
:
When CD34 ( + ) CD38 ( - ) hematopoietic progenitors were cultured with stem cell factor, flt3 ligand, thrombopoietin and IL-3, Delta-1, in combination with the IL-6R/IL-6 fusion protein FP6, increased the generation of glycophorin A ( + ) erythroid cells but counteracted the
effects of
IL-6 and FP6 on the generation of
CD14 ( + ) monocytic and CD15 ( + ) granulocytic cells
Regueiro et al., Eur Respir J 2009
:
IL-6 , IL-1beta and cigarette smoke condensate
induced the expression of LBP and
CD14 by airway epithelial cells
Chávez-Sánchez et al., Lipids in health and disease 2010
:
The activation of
CD14 , TLR4, and TLR2 by mmLDL
induces IL-1ß,
IL-6 , and IL-10 secretion in human monocytes and macrophages ... Blocking
CD14 in monocytes
inhibited secretion of interleukin (IL)-1ß ( 72 % ),
IL-6 ( 58 % ) and IL-10 ( 63 % ), and blocking TLR4 inhibited secretion of IL-1ß by 67 %, IL-6 by 63 % and IL-10 by 60 %
Jia et al., Zhonghua Kou Qiang Yi Xue Za Zhi 2011
:
Pe-LPS can
induce the expression of
IL-6 in osteoblast MC3T3-E1 through
CD-14 and TLR-4, but not TLR-2
Walter et al., Arthritis Rheum 2013
(Arthritis, Rheumatoid) :
The observed increase in IL-17 positive and IFN? positive Treg cells was driven by monocyte derived IL-1ß,
IL-6 , and TNFa and was
mediated by both CD14+CD16- and
CD14+CD16+ monocyte subsets
Brekke et al., Adv Exp Med Biol 2013
(Escherichia coli Infections...) :
Inhibiting complement and
CD14 efficiently
reduced the expression of the E. coli induced cytokines IL-1beta,
IL-6 , IL-8, and platelet derived growth factor bb
Ziegler-Heitbrock et al., Eur J Immunol 1994
:
This
CD14 molecule was functional in that lipopolysaccharide stimulation
induced interleukin (IL)-6 and IL-10 in clones 1 and 2 but not in clone 3
Dentener et al., J Immunol 1993
:
We conclude that
CD14 is
involved in LPS induced release of TNF-alpha,
IL-6 , and IL-8 by monocytes and alveolar macrophages and that this receptor appears to be able to recognize LPS directly in the absence of serum
Hasday et al., Am J Physiol 1997
:
Interleukin (IL)-6 increased
CD14 expression in both BAM and PBM but exerted different effects on CD14 distribution in these cell types
Matsumoto et al., Int Immunol 1998
(Leukemia, Monocytic, Acute) :
Inducible expression of nuclear factor
IL-6 increases endogenous gene expression of macrophage inflammatory protein-1 alpha, osteopontin and
CD14 in a monocytic leukemia cell line ... We demonstrated that inducible expression of
NF-IL6 is able to
increase endogenous gene expression of macrophage inflammatory protein (MIP)-1 alpha, osteopontin and
CD14 in M1 cells