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CISH — PLG

Text-mined interactions from Literome

Okuno et al., J Hepatol 1999 (Liver Cirrhosis, Experimental) : 9,13-di-cis-RA transactivated RARalpha, and provoked PA/plasmin and TGF-beta dependent procollagen synthesis in HSCs. 9,13-di-cis-RA levels were increased both in activated HSCs in vitro and in fibrotic liver accompanying the enhanced expression of RAR alpha/beta, PA, TGF-beta and procollagen in vivo
Wen et al., Am J Pathol 2005 (Fibrosis) : In human mesangial cells 9-cis-RA suppressed TGF-beta1 induced alpha-smooth muscle actin, fibronectin, and plasminogen activator inhibitor-1 expression, but it did not significantly affect cell proliferation and survival
Okuno et al., Hepatology 1997 (Liver Cirrhosis, Experimental) : In vitro SC cultures, 9-cis-RA enhanced cellular PA and plasmin levels thereby induced plasmin mediated activation of latent TGF-beta