◀ Back to EGFR
EGFR — EGR1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Nishi et al., Cancer Res 2002
(Osteosarcoma) :
We demonstrate that
early growth response factor 1 (Egr-1) , which is induced by hypoxia, can
activate the basal transcriptional activity of the
EGFR promoter ...
Egr-1 not only transactivates the EGFR promoter activity but also
enhances endogenous
EGFR expression ... Using a series of EGFR promoter deletion mutants, we show that the region between -484 and -389, which contains a putative Egr-1 consensus motif, is crucial for
EGFR transactivation by
Egr-1 ... Our results provide evidence that
regulation of
EGFR promoter activity by
Egr-1 represents a mechanism for epidermal cell growth during hypoxia
Zhao et al., Int J Cancer 2007
:
To verify that
Egr-1 mediated NT-induced
EGFR transcription, Egr-1 siRNA was used to knock down its expression
Sanchez-Guerrero et al., PloS one 2012
:
This study reports for the first time that
Egr-1 induction by IL-1beta
involves EGFR and MMP/ADAM dependent EGFR phosphorylation