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GNRH2 — MMP2

Text-mined interactions from Literome

Chou et al., J Clin Endocrinol Metab 2003 : Regulatory effects of gonadotropin releasing hormone (GnRH) I and GnRH II on the levels of matrix metalloproteinase (MMP)-2 , MMP-9, and tissue inhibitor of metalloproteinases-1 in primary cultures of human extravillous cytotrophoblasts ... Cetrorelix, a GnRH receptor antagonist, inhibited the regulatory effects of GnRH I, but not GnRH II , on MMP-2 , MMP-9, and TIMP-1 expression in these cells ... Collectively, these observations suggest that GnRH I and GnRH II differentially regulate MMP-2 , MMP-9, and TIMP-1 expression in human trophoblasts, possibly via distinct receptor mediated intracellular signaling pathways
Poon et al., Mol Endocrinol 2011 (Neoplasm Invasiveness...) : 37-kDa laminin receptor precursor mediates GnRH-II induced MMP-2 expression and invasiveness in ovarian cancer cells ... Importantly, LRP siRNA treatment abolishes GnRH-II induced MMP-2 production, and invasion in OVCAR-3 and CaOV-3 cells, which was also seen after MMP-2 siRNA treatment