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Hiebert et al., Blood Cells Mol Dis 2003
(Acute Disease...) :
We found that
AML1-ETO repressed the promoter of p14(ARF) tumor suppressor in transient transfection assays and
reduced endogenous levels of
p14(ARF) expression in multiple cell types
Shikami et al., Leuk Res 2006
(Leukemia, Myeloid, Acute...) :
In this study, the mRNA expression of p14(ARF) in t ( 8 ; 21 ) AML cells was found to be significantly lower than acute myelocytic leukemia ( AML ) cells without t ( 8 ; 21 ) chromosome abnormality, which was concordant with previous observation by Linggi et al. that
AML1-MTG8 represses the transcription of
p14(ARF)