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EGF — LIN9

Text-mined interactions from Literome

Sternberg et al., WormBook : the online review of C. elegans biology 2005 : EGF-receptor and Notch signaling are antagonistic : EGF-receptor signaling leads to down-regulation of the Notch-like receptor LIN-12 , while LIN-12 signaling induces negative regulators of EGF-receptor signaling such as MAP kinase phosphatase LIP-1 and the tyrosine kinase ARK-1
Yu et al., Dev Biol 2009 : Nonetheless, the overall logic is similar in the VPCs and the HCG : EGF and/or WNT induce a 1 degree lineage, and LIN-12/NOTCH induces a 2 degrees lineage
Karp et al., Proc Natl Acad Sci U S A 2013 : When hermaphrodites are grown under favorable conditions, the EGF mediated `` inductive '' signal and the LIN-12/Notch mediated `` lateral '' signal confer a precise spatial pattern of distinct vulval cell fates in the third larval stage, a day after hatching
Li et al., Carcinogenesis 2013 (Carcinoma, Non-Small-Cell Lung...) : To the best of our knowledge, this study is the first to report that PTTG1 promotes epidermal growth factor (EGF) induced the phosphorylation of LIN-11 , Isl1 and MEC-3 protein domain kinase and cofilin, a critical step in cofilin recycling and actin polymerization