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Song et al., American journal of physiology. Renal physiology 2002 : We investigated the effects of low-density lipoprotein (LDL) on PA inhibitor-1 (PAI-1), urokinase-type PA (uPA) , and tissue-type PA (tPA) in relationship to protein kinase C ( PKC ) in cultured human mesangial cells ( HMC ) ... The stimulatory effects of LDL on PAI-1, tPA, and uPA gene regulation in HMC were blocked by the inhibition of PKC using GF-109203X 12 h after treatment with LDL or downregulation of PKC using phorbol myristate acetate ... In summary, LDL regulates PAI-1, uPA , and tPA in biphasic patterns in HMC, and the upregulation of PAI-1, uPA, and tPA after long-term LDL exposure seems to be mediated by a delayed PKC activation associated with an increased PA inhibitory activity
Beaudeux et al., Clin Chim Acta 2004 (Inflammation) : uPA monocyte expression was stimulated by either copper ions oxidised or O2*-/HO* free radical oxidised LDL