Gene interactions and pathways from curated databases and text-mining

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IRF7 — RELA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Zhang et al., J Virol 2001 : In addition, NF-kappaB is involved in the induction of IRF-7 ... A superrepressor of IkappaB ( sr-IkappaB ) could block the induction of IRF-7 by LMP-1, and overexpression of NF-kappaB ( p65 plus p50 ) could induce the expression of IRF-7
Dai et al., J Immunol 2004 : In this study, we demonstrate that both LPS and HSV up-regulate the expression of IRF-7 in PDC, and that this enhancement of IRF-7 is dependent on NF-kappa B activation
Song et al., Proc Natl Acad Sci U S A 2008 : Association with active LMP1 signaling complexes was also critical for IRF7 activation because (i) a dominant negative IRF7 bound to LMP1, blocked IRF7 association and activation, but did not inhibit LMP1 induced NF-kappaB or TBK1 or Sendai virus mediated IFN stimulated response element activation ; and ( ii ) two different LMP1 transmembrane domain mutants, which fail to aggregate, each bound IRF7 and prevented LMP1 from binding and activating IRF7 in the same cell, but did not prevent NF-kappaB activation
Cheng et al., J Interferon Cytokine Res 1998 : Therefore, effective ISRE activity of IP-10 VRE may require an IRF-like protein binding, which is enhanced by an NF-kappaB heterodimer binding to an adjacent KB site