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IRF7 — RELA
Pathways - manually collected, often from reviews:
-
BioCarta the information processing pathway at the ifn beta enhancer:
IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
ATF-2 (ATF2)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
HMG1 (HMGB1)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50 complex (RELA)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50 complex (RELA)
→
IRF (IRF5/IRF1/IRF3/IRF6/IRF7/IRF4/IRF2)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
→
IRF (IRF5/IRF1/IRF3/IRF6/IRF7/IRF4/IRF2)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
→
c-JUN (JUN)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
PCAF
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
→
histone transacetylase (CREBBP)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
hSWI/SNF complex (SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
hSWI/SNF complex (SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
FastForward regulation:
NFKB1, RELA
→
IRF7
(transcriptional regulation, increase)
Lu et al., J Biol Chem 2000*
Evidence: PROMACTIVITY, DNABINDING
Text-mined interactions from Literome
Zhang et al., J Virol 2001
:
In addition,
NF-kappaB is
involved in the induction of
IRF-7 ... A superrepressor of IkappaB ( sr-IkappaB ) could block the induction of
IRF-7 by LMP-1, and overexpression of
NF-kappaB ( p65 plus p50 ) could
induce the expression of IRF-7
Dai et al., J Immunol 2004
:
In this study, we demonstrate that both LPS and HSV up-regulate the expression of IRF-7 in PDC, and that this enhancement of
IRF-7 is
dependent on
NF-kappa B activation
Song et al., Proc Natl Acad Sci U S A 2008
:
Association with active LMP1 signaling complexes was also critical for IRF7 activation because (i) a dominant negative IRF7 bound to LMP1, blocked IRF7 association and activation, but did not
inhibit LMP1 induced
NF-kappaB or TBK1 or Sendai virus mediated IFN stimulated response element activation ; and ( ii ) two different LMP1 transmembrane domain mutants, which fail to aggregate, each bound
IRF7 and prevented LMP1 from binding and activating IRF7 in the same cell, but did not prevent NF-kappaB activation
Cheng et al., J Interferon Cytokine Res 1998
:
Therefore, effective ISRE activity of IP-10 VRE may require an
IRF-like protein binding, which is
enhanced by an
NF-kappaB heterodimer binding to an adjacent KB site